By: Katherine Flamm, M.S. (biology) CNS


The News:  The breakthrough health product ASEA that is now being featured in the Wellness Village under the name Sea-Change was given additional scientific credentials with the presentation of a second study to the Federation of American Societies for Experimental Biology (FASEB) conference in April of this year. In case you don’t know about that organization, here’s a brief history.

FASEB is now recognized as the policy voice of biological and biomedical researchers.

Founded in 1912, the Federation of American Societies for Experimental Biology was originally created by three independent scientific organizations to provide a forum in which to hold educational meetings, develop publications, and disseminate biological research results. What started as a small group of dedicated scientists has grown to be the nation’s largest coalition of biomedical researchers, representing 27 scientific societies and over 110,000 researchers from around the world. The FASEB Journal ranks among the top biology journals in the world.

The study presented to the FASEB conference was also published in their journal in April of this year. Here’s how The FASEB Journal stacks up in reputation and influence in the scientific community.

This monthly journal publishes peer-reviewed, multidisciplinary original research articles, as well as editorials, reviews, and news of the life sciences. As disciplines in the life sciences continue to overlap, readers are drawn to The FASEB Journal for its interdisciplinary coverage. The FASEB Journal was recognized as one of the Top 100 Most Influential Journals of the past century in Biology and Medicine by the Special Library Association’s Biomedical and Life Sciences Division. Further, it has been covered by major news outlets including The Chicago Tribune, ABC News, Scientific American, and The New York Times.

The Studies – April, 2013:  The study presented in April of this year showed how the consumption of ASEA influenced endurance in mice. Although a mouse study might seem far from a human study, in fact most studies use mice as they have some striking similarities with humans. The amazing thing about this study is the increase in endurance that was evidenced by these mouse subjects – a 29% increase in endurance is astounding! An increase in endurance would translate as a big positive for human beings in all aspects of life.

Effects of ASEA beverage intake on endurance performance in mice  Amy M Knab, David C Nieman, R. Andrew Shanely, Jennifer J Zwetsloot, Lynn Cialdella-Kam and Mary Pat Meaney Appalachian State University, Human Performance Laboratory, North Carolina Research Campus, Kannapolis, NC.

Previous research with ASEA (a saline beverage with stable superoxide complexes) found increased fatty acid mobilization in cyclists after 7 d ingestion. We hypothesized that run time to exhaustion would be favorably influenced by ASEA intake due to enhanced fatty acid oxidation and muscle glycogen sparing.

Conclusion:  ASEA increased run time to exhaustion by 29% in mice, potentially through less inhibition of fatty acid oxidation via increased P-ACC, and muscle glycogen sparing percent (30%).

FASEB J. April 2013 27 (Meeting Abstract Supplement) 713.1

April, 2012 Study:  A previous study presented to last year’s FASEB conference concluded that when human athletes consumed, for one week, the product ASEA they experienced an increase in exercise performance due to increased fat oxidation and amino acid sparing. What that means is that instead of relying on glycogen for exercise performance and drawing down muscle stores these athletes started burning their own fat stores at a higher rate. This study shows that the consumption of ASEA has a measurable and powerful effect on human metabolism. You don’t have to be an elite athlete to reap benefits from a big and beneficial change in metabolism.

Influence of a redox-signaling supplement on biomarkers of physiological stress in athletes: a metabolomics approach  R. Andrew Shanely1, David C. Nieman1, Dru A. Henson1, Amy M. Knab1, Lynn Cialdella-Kam1, Mary Pat Meaney1, Sara Baxter2 and Wei Sha3.

We determined if drinking ASEA™, a redox-signaling molecule beverage, would improve cycling performance, counter inflammation, oxidative stress, and immune dysfunction, and alter the metabolite profile.

Conclusion:  Linear modeling found that ASEA supplementation caused a significant shift in 43 metabolites pre-Ex, especially free fatty acids, suggesting an enhanced fat oxidation and amino acid sparing, with an increase in ascorbic acid, during Ex. Within the context of this study, 1-wk ASEA supplementation caused extensive fatty acid mobilization before and during Ex, with no apparent influence on TT performance and traditional biomarkers of inflammation, oxidative stress, and immunity.

  1. Human Performance Laboratory, Appalachian State University, UNC-Charlotte, North Carolina Research Campus, Kannapolis, NC
  2. Analytical Sciences, David H. Murdock Research Institute, UNC-Charlotte, North Carolina Research Campus, Kannapolis, NC
  3. Bioinformatics Services Division, UNC-Charlotte, North Carolina Research Campus, Kannapolis, NC.

FASEB J. April 2012 26 (Meeting Abstract Supplement) lb713

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